This church and convent were built by Cardinal Giacomo Savelli, who was later to become Pope Honorius IV, in about 1710, on the occasion of the visit of Pope Clement XI Albani to Albano, the painter G. van Wittel depicted the church and the adjoining convent. This splendid canvas is now in the museum of Palazzo Pitti in Florence.

In 1769 Cardinal Marco Antonio Colonna restored the whole building completely: especially the interior of the church was changed considerably, giving it a rather elaborate Baroque appearance, while the façade is in neoclassical style.

The painting above the altars are from the 17^th and 18^th centuries. The most noteworthy is the one above the high altar that represents the anointment of St. Paul, a late 17^th century work by a painter of the school of Pietro Cortona.

The vault of the aisle is decorated with a fine 19^th-cantury fresco that can be attributed to Gagliardi, a painter who was very active in Albano at that time.

Under the altar in the chapel on the keft there is the body of St. Caspar del Bufalo, the founder of the Missionaries of the Precious Blood.

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